Drug:
GENERIC NAME: ibuprofen
Side effects: (15)
gastrointestinal
ulcerations
abdominal burning
pain
cramping
nausea
gastritis
serious gastrointestinal bleeding
liver toxicity
stomach ulceration and bleeding can occur without any abdominal pain
Black tarry stools
weakness
dizziness upon standing may be the only signs of internal bleeding
Rash
kidney impairment
ringing in the ears
lightheadedness
Precautions: (13)
DRUG INTERACTIONS: Ibuprofen should be avoided by patients with a history of asthma attacks, hives or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Ibuprofen is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding. Patients taking lithium can develop toxic blood lithium levels. Children's Advil and Children's Motrin are approved for use in children, 6 months and older, to treat fever, pain, and symptoms of arthritis. Ibuprofen is not habit forming. NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines. Ibuprofen is best discontinued at least two days in advance of the procedure.
OTHER
As with other NSAIDs, long-term administration of ibuprofen has resulted in renal papillary necrosis and other renal pathologic changes. Renal toxicity has also been seen in patients in which renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a nonsteroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly. Discontinuation of nonsteroidal anti-inflammatory drug therapy is usually followed by recovery to the pretreatment state.
Ibuprofen metabolites are eliminated primarily by the kidneys. The extent to which the metabolites may accumulate in patients with renal failure has not been studied. Patients with significantly impaired renal function should be more closely monitored.
Source:
Both sources are © copyright material and are from these links
http://www.medicinenet.com/ibuprofen/article.htm